Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 1.085


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA6chr7_-_27187367-0.462.5e-01Click!
HOXB7chr17_-_46687925-0.363.8e-01Click!
HOXA7chr7_-_271961630.275.2e-01Click!
HOXB6chr17_-_46682333-0.275.2e-01Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_31352489 1.537 NM_001253827
 GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr7_-_83824216 1.533 NM_006080
 SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr2_+_177016112 1.077 NM_014621
 HOXD4
homeobox D4
chr12_+_41831484 1.002 NM_013377
 PDZRN4
PDZ domain containing ring finger 4
chr18_+_61554938 0.999 NM_001143818
NM_002575
 SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr12_-_71031174 0.966 NM_001109754
 PTPRB
protein tyrosine phosphatase, receptor type, B
chr2_-_161056573 0.940 NM_000888
 ITGB6
integrin, beta 6
chr11_-_115088628 0.936 CADM1
cell adhesion molecule 1
chr2_+_177016337 0.911


chr2_-_161056762 0.895 ITGB6
integrin, beta 6
chr12_-_105322056 0.844 NM_032148
 SLC41A2
solute carrier family 41, member 2
chr7_-_41742666 0.779 NM_002192
 INHBA
inhibin, beta A
chr13_-_103719195 0.773 NM_000452
 SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr8_+_104831415 0.753 NM_014677
 RIMS2
regulating synaptic membrane exocytosis 2
chr3_+_130569368 0.745 NM_001199180
NM_001199181
NM_001199182
 ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr12_-_28124915 0.742 NM_002820
NM_198965
 PTHLH

parathyroid hormone-like hormone

chr17_-_39093671 0.729 NM_015515
 KRT23
keratin 23 (histone deacetylase inducible)
chr11_+_20620945 0.718 NM_004211
 SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr8_-_122653493 0.705 NM_005328
 HAS2
hyaluronan synthase 2
chr5_-_24645084 0.698 NM_006727
 CDH10
cadherin 10, type 2 (T2-cadherin)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 128 entries
enrichment   p-value GO term description
2.90 2.52e-03 GO:0051781 positive regulation of cell division
2.68 3.29e-05 GO:0022612 gland morphogenesis
2.67 5.58e-03 GO:0070848 response to growth factor stimulus
2.63 2.83e-03 GO:0016202 regulation of striated muscle tissue development
2.54 6.53e-03 GO:0048634 regulation of muscle organ development
2.51 9.29e-04 GO:0048638 regulation of developmental growth
2.49 1.68e-02 GO:0050680 negative regulation of epithelial cell proliferation
2.37 2.02e-03 GO:0048706 embryonic skeletal system development
2.34 4.21e-02 GO:0030518 steroid hormone receptor signaling pathway
2.28 4.84e-02 GO:0009953 dorsal/ventral pattern formation
2.06 8.08e-04 GO:0050678 regulation of epithelial cell proliferation
2.00 1.79e-03 GO:0045165 cell fate commitment
1.97 9.89e-05 GO:0048732 gland development
1.96 4.38e-02 GO:0033273 response to vitamin
1.95 2.79e-02 GO:0001763 morphogenesis of a branching structure
1.92 1.03e-04 GO:0043193 positive regulation of gene-specific transcription
1.90 3.52e-02 GO:0007156 homophilic cell adhesion
1.88 1.12e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.84 2.64e-02 GO:0009952 anterior/posterior pattern formation
1.82 3.73e-09 GO:0051094 positive regulation of developmental process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
3.45 2.78e-03 GO:0045178 basal part of cell
2.53 9.74e-03 GO:0031093 platelet alpha granule lumen
2.48 1.44e-02 GO:0034774 secretory granule lumen
2.40 1.76e-02 GO:0031983 vesicle lumen
2.39 8.56e-03 GO:0031091 platelet alpha granule
2.38 3.03e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
1.91 1.92e-02 GO:0044420 extracellular matrix part
1.80 2.14e-03 GO:0030424 axon
1.73 7.37e-04 GO:0016323 basolateral plasma membrane
1.61 1.24e-03 GO:0005578 proteinaceous extracellular matrix
1.59 1.30e-04 GO:0045202 synapse
1.58 4.14e-04 GO:0009986 cell surface
1.57 8.87e-07 GO:0030054 cell junction
1.51 8.42e-03 GO:0031012 extracellular matrix
1.45 3.60e-02 GO:0043005 neuron projection
1.36 1.51e-04 GO:0044421 extracellular region part
1.34 1.67e-10 GO:0044459 plasma membrane part
1.31 2.13e-02 GO:0042995 cell projection
1.31 4.94e-02 GO:0005615 extracellular space
1.24 3.95e-02 GO:0031226 intrinsic to plasma membrane

Gene overrepresentation in function category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
2.40 3.00e-02 GO:0051015 actin filament binding
2.37 2.49e-02 GO:0042562 hormone binding
1.90 7.49e-05 GO:0010843 promoter binding
1.88 7.38e-05 GO:0000975 regulatory region DNA binding
1.88 7.38e-05 GO:0001067 regulatory region nucleic acid binding
1.88 7.38e-05 GO:0044212 transcription regulatory region DNA binding
1.82 7.54e-03 GO:0008083 growth factor activity
1.77 4.13e-02 GO:0046873 metal ion transmembrane transporter activity
1.68 4.64e-02 GO:0003682 chromatin binding
1.61 5.05e-09 GO:0043565 sequence-specific DNA binding
1.53 3.18e-02 GO:0016563 transcription activator activity
1.48 3.93e-02 GO:0000988 protein binding transcription factor activity
1.48 3.93e-02 GO:0000989 transcription factor binding transcription factor activity
1.46 1.60e-04 GO:0005509 calcium ion binding
1.45 2.00e-07 GO:0030528 transcription regulator activity
1.45 5.91e-07 GO:0001071 nucleic acid binding transcription factor activity
1.45 5.91e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.42 2.97e-06 GO:0005102 receptor binding
1.12 8.58e-06 GO:0005515 protein binding